The aggressive and rapidly lethal brain tumor glioblastoma (GBM) is associated with profound tissue stiffening and genomic lesions in key members of the epidermal growth factor receptor (EGFR) pathway.Previous studies from our laboratory have shown that increasing microenvironmental stiffness in culture can strongly enhance glioma cell behaviors re
The structure and function of the sarcomere of striated muscle is well studied but the steps of sarcomere assembly and maintenance remain under-characterized.With the aid of chaperones and factors of the protein quality control system, Fridge Control Module muscle proteins can be folded and assembled into the contractile apparatus of the sarcomere.
Abstract Fridge Control Module Under the shared big data environment, the existing shared data auditing schemes rarely consider the authorization management of group users.Thus, in this paper, we propose a novel remote shared data checking possession scheme that support group authority management.To implement group user rights management, we firstl
Abstract Laparoscopic TAPP/TEP approaches are well-established options for the cure of inguinal hernias.As in the open approach, mesh fixation and poor-quality biologic response represent controversial questions and are a source of concerns.Furthermore, hernia defect patency represents another problem which seems not well acknowledged among surgeon
The article examines C-500 the key ethical issues that must be addressed in any study involving children and adolescents who are victims of violence and abuse.Psychological research and intervention is a social interaction and focus on achieving positive social goals, organization and holding of which requires compliance with professional ethical s